Product Instruction
鈼?nbsp;LMCA, L-methylfolate is the biologically active form of vitamin B9. That means it is the form the human body can actually use in circulation.
鈼?nbsp;It goes by several other common names including:
Methylfolate
L-Methylfolate calcium (refers to the calcium salt molecule it is attached to)
Metafolin and Deplin
5-MTHF and L-5-MTHF (in this article 5-MTHF refers to L-5-MTHF)
Levomefolic acid
5-methyltetrahydrofolate
(6S)-5-methyltetrahydrofolate and Quatrefolic

鈼?nbsp;It is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.
鈼?nbsp;It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).
鈼?nbsp;L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml).

Specification of L-methylfolate calcium USP
ITEMSSPECIFICATIONSMETHOD
CharactersPowderOrganoleptic
AppearanceWhite to light yellowish crystalline powderOrganoleptic
Solubility

Sparingly soluble in water and very slightly soluble
or insoluble in most organic solvents; soluble in
alkaline solutions

In-House
Loss on drying6.0%~17.0%Karl Fischer
Calcium (anhydrous basis)7.0%~8.5%–
Bulk density0.5~0.6g/ml–
Identification:
HPLC/TLC
A. Infrared absorption
—
B. Test of calcium
—
C. Retention time (HPLC)
—
Assay (anhydrous solvent-free basis)95.0%~102.0%HPLC
D-5-Methylfolate鈮?.0%–
Impurities
Chloride鈮?.5%–
Heavy Metals鈮?0ppm–
As鈮?.5ppm–
Pb鈮?.0ppm–
Hg鈮?.1ppm–
Cd鈮?.5ppm–
Residual solvents
Ethanol鈮?.5%–
2-Propanol鈮?.5% —
Microbiological
Total Plate Count 1000cfu/g Max–
Yeast& Mold100cfu/g Max–
E.Coli colonies/gNegative (-)–
Mites /gNegative (-)–
Product benefits
鈼?nbsp;Major depressive disorder
Preliminary research suggests that levomefolic acid (L-methylfolate) taken with a first-line antidepressant may provide an adjunctive antidepressant effect for individuals who do not respond or have only a partial therapeutic response to SSRI or SNRI medication.
鈼?nbsp;Diabetic neuropathy
Early studies show L-Methylfolate supplementation may be beneficial in treating severe depression and diabetic neuropathy.
鈼?nbsp;Supplementing L-Methylfolate is the clear alternative while pregnant.
Supplementing with L-Methylfolate while pregnant is the clear alternative for those who suspect an issue with metabolising folic acid.
鈼?nbsp;Cardiovascular disease and cancer
L-methylfolate has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. It bypasses several metabolic steps in the body and better binds thymidylate synthase with FdUMP, a metabolite of the drug fluorouracil.High quality Agent Nutraceutical Actives
website:http://www.yougubio.com/superfood-ingredients/agent-nutraceutical-actives/